1_22_09_EnzymaticCascades

1_22_09_EnzymaticCascades - The two types of postsynaptic...

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Unformatted text preview: The two types of postsynaptic receptors are ionotropic (direct) and metabotropic (indirect). Photoreceptor hyperpolarization with light increases in a graded manner with intensity. Photo- transduction begins with numerous pigment molecules ( e.g. , rhodopsin) on the discs of rods or on folds of cones membranes. A G-protein enzymatic cascade links rhodopsin to ionic channels in phototransduction. Photoreceptor hyperpolarization with light increases in a graded manner with intensity. However, responses are nonlinear, e.g. , peaks occur earlier for high light-flash intensities. Can models of G-protein enzymatic cascades explain the nonlinearities? A G-protein enzymatic cascade links rhodopsin to ionic channels in phototransduction. dR * dt = t ( ) 1 + K r c n r 1 R R * + R i b Notation: , light; R* and R i , active and inactive Rhodopsin; c, Ca 2+ concentration....
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1_22_09_EnzymaticCascades - The two types of postsynaptic...

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