1_22_09_EnzymaticCascades

1_22_09_EnzymaticCascades - Outline of the Lecture Outline...

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Unformatted text preview: Outline of the Lecture Outline of the Lecture Cascades of Enzymatic Reactions Cascades of Enzymatic Reactions Phototransduction G-protein Cascade and Ca Phototransduction G-protein Cascade and Ca 2+ 2+ Control Control Enzymatic-cascade Models Enzymatic-cascade Models Involve Systems of Involve Systems of Michaelis-Menten Kinetic Michaelis-Menten Kinetic Equations Equations The two types of postsynaptic receptors are ionotropic (direct) and metabotropic (indirect). Photoreceptor hyperpolarization with light increases in a graded manner with intensity. Photo- transduction begins with numerous pigment molecules ( e.g. , rhodopsin) on the discs of rods or on folds of cones membranes A G-protein enzymatic cascade links rhodopsin to ionic channels in phototransduction. Photoreceptor hyperpolarization with light increases in a graded manner with intensity. However, responses are nonlinear, e.g. , peaks occur earlier for high light-flash intensities. Can models of G-protein enzymatic cascades explain the nonlinearities? A G-protein enzymatic cascade links rhodopsin to ionic channels in phototransduction.to ionic channels in phototransduction....
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1_22_09_EnzymaticCascades - Outline of the Lecture Outline...

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