1_29_09_PresynapticMechanisms

1_29_09_PresynapticMechanisms - Outline of the Lecture...

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Outline of the Lecture Outline of the Lecture Models of Neurotransmitter Release Models of Neurotransmitter Release [Ca [Ca 2+ 2+ ] ] in in              Quantal Release             Facilitation and               Quantal Release             Facilitation and  Depression Depression      
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Models of Transmitter Take  Models of Transmitter Take  into Account [Ca into Account [Ca 2+ 2+ ] ] in in  and   and  Vesicle Availability Vesicle Availability    
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This circuit’s function depend on nonlinear synaptic mechanisms.
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Transmitter release is due to Ca 2+ -induced vesicle fusion at the presynaptic terminal.
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A low [Ca 2+ ] out condition shows that the release of transmitters is quantal and probabilistic.
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If the number of vesicles is large and the probability of release is low, then one can approximate the quantal release with a Poisson distribution: P ( m ) = λ μ μ! ε variance m ( 29 = Π(μ 29 μ - λ ( 29 2 μ=0 = λ mean m ( 29 = Π(μ 29 μ = λ
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A low [Ca 2+ ] out condition shows that the release of transmitters is quantal and probabilistic.
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The solid line is the sum of several Gaussian distributions weighed by a Poisson distribution.
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1_29_09_PresynapticMechanisms - Outline of the Lecture...

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