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Nerve stimulation 2009

Nerve stimulation 2009 - Nerve Stimulation BME 552 February...

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2/5/2009 1 Nerve Stimulation BME 552 February 6, 2009 Today’s Business HW2 due Monday at 5PM to Tim Nayar HW3 available on blackboard • Reading – Rattay*, McNeal, Shannon*, McCreery Change to Syllabus – Next week finish nerve stim, retinal prosthesis – Feb. 20 th Circuits for neural stim; DBS; Neuromuscular, Summary of first part of class
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2/5/2009 2 Overview of next 5 classes We will examine the signal path from current generator to neurons (not in that order) Class 2-3 – Electrodes/Packaging Class 4-5 – Stimulating neural activity: short, medium, long-term effects Class 5 – Circuits for neural stimulation Class 6 – applications of neural stim: retina, deep brain stimulation, peripheral nerve For now, assume circuit has power and data source Overview of this class How are nerves activated by extracellular l t d ? electrodes? Measures of neural response Muscle vs. nerve stimulation Manipulation of nerve response Temporary changes in neural excitability Neural damage from stimulation
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2/5/2009 3 Models of Neural Activation Step #1: Determine potential distribution in tissue from stimulation – V = ρ I electrode /4 π r for homogeneous – Numerical methods for heterogeneous conductivity Step #2: Make compartment model of neuron and apply voltages as input Step #3: Membrane conductance changes following HH models (or similar) Electrical model for unmyelinated axon Extracellular Stimulating electrode Axon McNeal, 1976, Rattay, 1986
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2/5/2009 4 Definitions and constants
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2/5/2009 5
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2/5/2009 6 Generalized Neuron in Electric Field Neuron is broken up into small sections R and C depend on different anatomy – Soma, dendrites, and axons are different shapes Ion channel populations are different
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