Lecture 15, Vitamin D...

Lecture 15, Vitamin D... - BCH/BMD 120 Spring 2008 Outline...

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BCH/BMD 120 Spring 2008 Outline for Lecture #13 VITAMIN D / BONE REMODELING / CLINICAL ASPECTS OF CALCIUM REGULATING HORMONES I. Vitamin D A. Prohormone (7-dehydrocholesterol) B. D 2 vs. D 3 C. Vitamin vs. hormone D. Irradiation scheme E. Metabolism F. Mode of action 1. Receptor for 1 α ,25(OH) 2 D 3 2. Genes regulated 3. Gene transcription 4. Intestine 5. Bone 6. Kidney II. Bone remodeling III. Disease States
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C Cholesterol HO D A B 1 2 3 4 5 6 7 8 14 15 16 9 10 19 11 12 18 17 20 23 25 26 27 24 22 21 13 C Cortisol (A classic steroid hormone) O D A B OH CO CH 2 OH C 7-Dehydrocholesterol (Pro-Vitamin D 3 ) HO D A B 3 5 6 7 10 19 18 17 20 23 25 22 C Vitamin D 3 or Cholecalciferol HO D A B 3 5 6 7 19 18 20 23 25 22 1 9 8 HO Sunlight (Natural process) A C D 1 3 5 6 7 8 9 19 18 20 23 25 22 HO
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Vitamin D 3 Vitamin D 2 7-Dehydrocholesterol Ergosterol Precursor: Production in humans: Skin by UV None Activity in humans: Fully active 1/3 that of D 3 Vitamin D 2 is much less active than D 3 in humans, J. Armas et al. JCEM 89:5387 (2004) H HO H OH H HO H H HH H H HO H
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CORE VITAMIN D METABOLISM 1 α ,25(OH) 2 D 3 is A STEROID HORMONE !! HO OH HO OH OH LIVER K I D N E Y Target Tissues BIOLOGICAL RESPONSES !! Vitamin D 3 A C D (3 β ) D (3 β ) A C D (3 β ) C A 25(OH)D 3 Thus the KIDNEY is also an ENDOCRINE GLAND that produces a STEROID HORMONE . OH . OH . OH 1 α ,25(OH) 2 -vitamin D 3 Vitamin D is inert.
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This note was uploaded on 06/08/2009 for the course BCH 120 taught by Professor Luben,norman,henry during the Spring '09 term at UC Riverside.

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Lecture 15, Vitamin D... - BCH/BMD 120 Spring 2008 Outline...

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