Lecture 16 - Lecture # 16 EICOSANOIDS BIOCHEMISTRY 120...

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BIOCHEMISTRY 120 Spring, 2009 Lecture # 16 EICOSANOIDS Helen L. Henry
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EICOSANOIDS I. General Characteristics II. Structure and Nomenclature III. Synthesis and Catabolism IV. Example of Biological Acitivity
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1. The eicosanoids are a large family of molecules derived from 20- ( eicosa -) carbon fatty acids. 2. The first members of the family were isolated from semen “prostaglandins”. 3. Eicosanoids are produced and act locally - autocrine/paracrine. 4. Eicosanoids are produced by and act on virtually all cells. 5. They participate in most if not all endocrine pathways. Characteristics of Eicosanoids
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nervous system - pain perception temperature regulation smooth muscle cells - alimentary reproductive respiratory (leukotrienes) vascular blood cells - erythrocytes leukocytes platelets Some Biological Effects of Eicosanoids
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PGA PGE PGF E: Ether-soluble non-polar, hydrohobic F: Phosphate-soluble polar, hydrophilic PGE 1 : one double bond in side chains PGE 2 : two double bonds in side chains Ring structure: Side Chains: Structure and Nomenclature of Prostaglandins α
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# Double bonds in eicosanoic acid # Double bonds in eicosanoid 3 1 4 2 5 3 Origin of Double Bonds Essential fatty acids
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This note was uploaded on 06/08/2009 for the course BCH 120 taught by Professor Luben,norman,henry during the Spring '09 term at UC Riverside.

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Lecture 16 - Lecture # 16 EICOSANOIDS BIOCHEMISTRY 120...

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