Lecture 17, Bone, Summary & Osteoporosis

Lecture 17, Bone, Summary & Osteoporosis - BCH-120...

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Unformatted text preview: BCH-120 Spring 2008 LECTURE #14 Calcium Homeostasis Summary & Osteoporosis Introduction ORIGINS OF THE OSTEOCLAST From R. A. Luben RANK = Receptor Activator of NFkB ligand RANKL = Ligand for RANK OPG = Osteoprotegrin, a decoy receptor for RANK which blocks actions of RANKL collagen Bone resorption vs deposition osteoblasts/osteoclasts; RANKL, RANK and osteoprotegerin (OPG) Vitamin D (- ) Calcitonin I. Vitamin D continued I. Vitamin D continued II. Bone Remodeling continued DISEASE STATES IN MAN RELATED TO VITAMIN D Non-USA USA Non-USA Non-USA Approved use of 1,25(OH)2D3 as a drug A. Rickets 1. Lack of UV light 2. Mutation in Vitamin D receptor 3. Malabsorption of Vit D 4. Liver disease (conversion defect) 5. Kidney disease (conversion defect) B. Hypervitaminosis D (increased osteoblst activity) C. Hyperparathroidism D. Chronic renal failure E. Osteoporosis DISEASE STATES III. Disease states continued B. Metabolic bone diseases a. Osteoporosis Decrease in bone mass Affects trabecular...
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This note was uploaded on 06/08/2009 for the course BCH 120 taught by Professor Luben,norman,henry during the Spring '09 term at UC Riverside.

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Lecture 17, Bone, Summary & Osteoporosis - BCH-120...

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