Lecture 18, Adrenal Morphology, Steroid Metab

Lecture 18, Adrenal Morphology, Steroid Metab - BCH/BMD 120...

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BCH/BMD 120 Spring 2008 Outline for Lecture #15 BACKGROUND ON STEROID METABOLISM/ ADRENAL MORPHOLOGY I. Background A. Cholesterol B. Steroid Families C. Sites of Metabolism D. Tropic Factors II. Adrenal Morphology A. Cortex B. Medulla III. Steroid Metabolism A. Cholesterol B. Progesterone C. Adrenal Sites of Metabolism 1. Zona Glomerulosa 2. Zona Fasiculata 3. Zona Reticularis
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Lecture #15A I. Background A. Cholesterol 1. Structure of cholesterol 2. Name of ring structure Cyclopentanoperhydrophenanthrene = Phenanthrene 3. Name of rings ABCD 4. Identification of asymmetric carbons 5. Orientation of hydroxyls α = “down” β = “up” HO HO
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A B CD 1 4 2 3 10 5 19 6 7 8 9 11 12 18 14 21 22 20 15 16 23 24 27 26 17 25 13 HO I. Background continued… A. Cholesterol continued… = Asymmetric carbons 2 n = 2 8 = 256 α = “down” β = “up”
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I. Background continued… B. Steroid Families
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I. Background continued… B. Steroid families continued… NOTE: These are not metabolic pathways; more like a family tree
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I. Background continued… C. Sites of Metabolism Aldosterone Testosterone Estradiol Adrenal Cortex Testes Ovary-Follicle
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I.
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This note was uploaded on 06/08/2009 for the course BCH 120 taught by Professor Luben,norman,henry during the Spring '09 term at UC Riverside.

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Lecture 18, Adrenal Morphology, Steroid Metab - BCH/BMD 120...

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