Lecture 19, Glutocorticoids

Lecture 19, Glutocorticoids - BCH/BMD 120 Spring 2008...

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BCH/BMD 120 Spring 2008 Outline for Lecture #16 GLUCOCORTICOIDS/DISEASE STATES I. Glucocorticoids A. Regulation of secretion B. Cellular basis of ACTH C. Biological effects 1. Blood transport 2. Effects D. Mode of Action E. Disease states 1. Cushings Disease 2. Primary Adrenal Insufficiency 3. Secondary Adrenal Insufficiency II. Congenital Adrenal Hyperplasia
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I. Glucocorticoids A. Regulation of secretion of glucocorticoids a. Adrenal cortex has no visible innervation b. Variations in secretion of cortisol are the RESULT of messages sent ONLY systemically through the blood stream LECTURE # 16 2008
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I. Glucocorticoids continued… *Stress Toxins Trauma Infection Exercise Pain Cold Exposure Nerve Impulse *Stress Noxious substances or cortisol CRF Neural Stimulator cortisol CRF ACTH ACTH Cortisol Midbrain Hypothalamus Adrenals Adenohypophysis (-) (+) ACTH
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I. Glucocorticoids continued… B. Cellular basis of ACTH action Actions of ACTH on cells of Zona Fasiculata 1. ACTH interacts with cell membrane receptor 2. Stimulate cAMP production (also open a Ca 2+ channel) 3. cAMP activates a protein kinase and phosphorylates proteins a. Hydrolysis of cholesterol esters b. Transport of cholesterol into mitochondria 4. Increased activity of cholesterol side-chain cleavage enzyme (the rate limiting step) 5. More pregnenolone is generated and ultimately more cortisol
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I. Glucocorticoids continued… Cholesterol storage ACTH and cortisol Production
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I. Glucocorticoids continued… Action of Glucocorticoid Receptor on a Target Cell
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I. Glucocorticoids continued…
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This note was uploaded on 06/08/2009 for the course BCH 120 taught by Professor Luben,norman,henry during the Spring '09 term at UC Riverside.

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Lecture 19, Glutocorticoids - BCH/BMD 120 Spring 2008...

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