Lecture 20, Blood pressure etc.

Lecture 20, Blood pressure etc. - BCH/BMD 120 Spring 2008...

Info iconThis preview shows pages 1–8. Sign up to view the full content.

View Full Document Right Arrow Icon
BCH/BMD 120 Spring 2008 Outline for Lecture #17 Mineralocorticoids/NAF/Endothelins/Kidney- Cardiovascular Regulation of Na + Volume and Blood Pressure I. Mineralocorticoids A. Regulation of secretion of aldosterone 1. Main actions of aldosterone 2. Functions of Juxtaglomerular (JG) apparatus 3. Renin 4. Angiotensin converting enzyme (ACE) 5. Angiotensin and adrenal zona glomerulosa B. Mode of action of aldosterone C. Disease states II. Atrial Natriuretic Factor (ANF) A. Biochemistry B. Biological Actions C. Integrated actions of Aldosterone and ANF
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Outline for Lecture #23 III. Endothelins A. Background on the cardiovascular system B. Biochemistry C. Biological actions IV. Kallikrein-Kinin pathway V. Nitric Oxide System VI. Homeostasis of fluid, electrolytes and blood pressure A. Water balance B. Cardiovascular system On Tuesday May 13 th there are the following events: (a) Quiz # 5 on Lectures [#17 & #18 ]. (b) A Clinical Correlate on “Blood Pressure Regulation”; three PDF files will be available for download by 11 Am today (Friday May 2 nd )
Background image of page 2
Lecture #23 I. Mineralocorticoids A. Regulation of secretion of aldosterone 1. Main actions of aldosterone a. Electrolyte and H 2 O metabolism b. Kidney distal tubule to promote Na + reabsorption NOTE: Since Na + (extracellular) and K + (intracellular) are intertwined, Aldosterone indirectly effects K + metabolism. 2. Function of Juxtaglomerular (JG) apparatus a. Filter many ions from blood b. Secrete renin Declining blood volume Declining blood pressure (hemorrhage) Declining Na + concentration (diets) Prolonged heat stress with sweat loss
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Schematic of Kidney Nephron
Background image of page 4
Counter- Current Exchange of Ions & H 2 O in Kidney Nephron
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
I. Mineralocorticoids continued… 3. Renin (an enzyme; 42k Da) a. Prepro-renin Pro-renin (406 a.a.) (386 a.a.) Renin (343 a.a.) b. Secreted by… JG cells of afferent arteriole Submaxillary gland of mouse c. Secretion by JG cells is regulated Increased Decreased Decreased renal Increased renal artery artery pressure pressure Decreased blood volume Decreased ECF Increased ECF PGI 2 ANF
Background image of page 6
I.
Background image of page 7

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 8
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 06/08/2009 for the course BCH 120 taught by Professor Luben,norman,henry during the Spring '09 term at UC Riverside.

Page1 / 28

Lecture 20, Blood pressure etc. - BCH/BMD 120 Spring 2008...

This preview shows document pages 1 - 8. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online