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Unformatted text preview: Lecture 19: Eukaryotic Gene Regulation 1 1. Define housekeeping and cell type-specific genes. Housekeeping genes (majority): genes expressed in most cell types required for general cell functions and cell viability. Ex: genes coding for enzymes of basic metabolism and proteins used for cell structures such as cytoskeleton and ribosomes Cell type-specific genes (few): Genes expressed in only particular cell types that perform functions specific of certain tissues. Ex: genes coding for immunoglobins/antibodies in B lymphocytes, growth hormone in somatotroph cells of the pituitary (brain), and albumin in hepatocytes of the liver) 2. The process of eukaryotic gene expression (Gene -> active protein product) is regulated at multiple levels; draw a diagram to show them. 3. How many RNA polymerases are involved in eukaryotic gene transcription and which classes of genes do they transcribe? 3 distinct eukaryotic RNA polymerases Class 1 genes are transcribed by RNA polymerase I (Pol I) r RNA Class 2 genes are transcribed by RNA polymerase I I (Pol I I) mRNA Class 3 genes are transcribed by RNA polymerase I I I (Pol I I I) tRNA & 5S rRNA 3. Describe major differences in the core promoter structures of class I class I I and class I I I genes? Pol I promoter: contains upstream promoter element & initiator core promoter element (INR) used for rRNA genes Pol I I promoter: contains proximal activating sequences, TATA box, and initiator (INR); The TATA box and initiator make up the core promoter; used for mRNA genes (protein-coding genes) Pol I I I promoter: contains intragenic promoter. (A-block, B-block) Pol I I I promoter: contains intragenic promoter....
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Lecture 19 done - Lecture 19: Eukaryotic Gene Regulation 1...

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