lec14 - LIPID ANABOLISM cetyl-CoA carboxylase fig 21-1...

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LIPID ANABOLISM
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fig 21-1 acetyl-CoA carboxylase
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fig 21-2 condensation
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fig 21-2 reduction
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fig 21-2 dehydration
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fig 21-2 reduction
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fig 21-4 synthesis of fatty acids…
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fig 21-4 synthesis of fatty acids…
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fig 21-5 acyl carrier protein (ACP) in E. coli a lot like…
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coenzyme A
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AcCoA-ACP transacetylase (AT) fig 21-6 (4th)
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malonyl-CoA- ACP transferase (MT) fig 21-6 fig 21-6 (4th)
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β -ketoacyl-ACP synthase (KS) fig 21-6 fig 21-6 (4th)
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β -ketoacyl-ACP reductase (KR) fig 21-6 fig 21-6 (4th)
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β - hydroxyacyl-ACP dehydratase (HD) fig 21-6 fig 21-6 (4th)
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enoyl-ACP reductase (ER) fig 21-6 fig 21-6 (4th)
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acetylCoA-ACP transacetylase (AT) fig 21-6 fig 21-6 (4th)
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fig 21-7
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fig 21-7
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fig 21-7 (4th) fatty acid synthases variations of the FAS complex
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Fatty acid synthesis: NADPH is where you find it! mammals, yeast: CYTOSOL plants: CHLOROPLAST high NADPH/NADP + ratio (75) low NADH/NAD + ratio (< .001) high NADPH/NADP + ratio (75)
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fig 21-9 two sources of NADPH…
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fig 21-10 citrate as a source of building blocks…
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fig 21-10 citrate lyase as an anabolic carbon source…
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fig 21-10 and a minor NADPH source… majority supplied by pentose phosphate pthwy
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fig 21-11 Allosteric regulation of fatty acid synthesis
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fig 21-11 Phosphorylation of fatty acid synthesis active un-phosphorylated AcCoAC makes cytosolic filaments
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fig 21-12 now what…?
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lec14 - LIPID ANABOLISM cetyl-CoA carboxylase fig 21-1...

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