lec18 - I believe that every human has a finite number of...

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I believe that every human has a I believe that every human has a finite number of heartbeats. I don't finite number of heartbeats. I don't intend to waste any of mine running intend to waste any of mine running around doing exercises. around doing exercises. Neil Armstrong Neil Armstrong QuickTimeª and a TIFF (Uncompressed) decompressor are needed to see this picture. QuickTimeª and a TIFF (Uncompressed) decompressor are needed to see this picture.
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5 routes for glucose 6-P LIVER fig 23-13
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routes for amino acids fig 23-14 LIVER
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routes for fatty acids major oxidative fuel of the liver fig 23-15 LIVER
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How do we think about the metabolic features of exercise?
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How to make ATP in muscle phosphagen glycolysis pyruvate oxidation lipolysis
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phosphocreatine: the muscle energy buffer
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muscle glycogen: the selfish tissue… (Glu) n Glu-1P Glu-6P glycogen phosphorylase P i phosphogluco- mutase Glu P i glycolysis This step requires Glu-6 phosphatase Liver-specific (Glu) n-1 Glycogen in muscle is not a direct source of blood glucose blood
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Remeber The Cori cycle? A way to replenish glucose during muscle activity fig 23-18
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muscle energy metabolism fig 23-5 muscle has no glu-6 phosphatase
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Anaerobic energy sources for muscle
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ATP maintenance in the first 3 minutes ATP PC lactate
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What about longer exercise times?
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adipocytes: specialized cells for fat storage, metabolism and signaling fig 23-16
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liver, muscle, adipocyte liver muscle adipocyte FFA lactate alanine Glu FA in VLDL
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Glucose vs. Fat as fuel Glucose + 6O 2 + 38ATP + 38Pi 2 2 palmitate + HS-CoA + 23O 2 + 96ATP + 96Pi 2 2 glucose 2 2 lipid 2 2 resting human RER is ~ 0.8
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(a bit) more ATP per O
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lec18 - I believe that every human has a finite number of...

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