Unformatted text preview: blood cell count can go down. x. No new proviruses will be made. In theory if we can keep production low, then T cells can do the rest, find infected cells and kill them. xi. Change Pol, change RT. Other NRTI’s look like other nucleoside. If HIV mutates Poll then… 7. “non nukes” (non-nucleoside analogs) NNRTI’s a. Bind RT, directly disable it. b. Nevirapine – good against vertical transmission. i. One pill for mother before labor, one pill for baby after = very effective ii. Same problem as above. Pol mutation, drug can’t bind to RT, then the virus is immune to this class of drugs....
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- Winter '09
- DNA, white blood cell, myopathy, mitochondrial DNA polymerase, azide blocks addition