15 - MIC170 5/21/09 Lecture 15 (Thursday, 5/21) Cell cycle...

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MIC170 – 5/21/09 1 Lecture 15 (Thursday, 5/21) Cell cycle control Yeast systems have been playing a leading role in eukaryotic cell cycle research 2001 Nobel Prize in physiology/medicine went to yeast researchers, L. Hartwell and P. Nurse --- the mechanism of cell cycle control is highly conserved between yeast and human Cell cycle (Fig. 16.5 from textbook) M (m itosis) and interphase------ S (= DNA s ynthesis) G1 and G2 (= g aps) One yeast cell cycle takes 1.5~2 hr One of the major regulatory points in the yeast cell cycle is “START” in late G 1 Cells can pass START only when ALL three conditions below are met; # cell size is big enough (Fig. 3-13 in handout-8) # availability of nutrients (if not, go to stationary phase) # no mating factor ( α or a factors arrest in G1 and shmoo) Mating G1 Stationary Phase (G0)
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MIC170 – 5/21/09 2 How to assess where cells are in the cell cycle? A.
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This note was uploaded on 06/11/2009 for the course MIC 170 taught by Professor Shiozaki during the Spring '09 term at UC Davis.

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15 - MIC170 5/21/09 Lecture 15 (Thursday, 5/21) Cell cycle...

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