Appendix A- Bone Physiology Lecture Supplement.ppt

Appendix A- Bone Physiology Lecture Supplement.ppt - Bone...

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•1 Bone Physiology This PowerPoint is to help you study the Bone Physiology Review Sheet handed out in Lab & Supplements the material in the Book
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Bone Cells Osteogenic cells – derived from mesenchyme; undergo cell division continuously; in periosteum, endosteum, & haversian canals. Osteoblasts – form matrix & collagen fibers; no division Osteocytes – osteoblasts trapped in the matrix they formed & maintain. Osteocytes in lacunae connected by gap junctions inside canaliculi. Osteoclasts – huge cells from fused monocytes function in bone resorption; destroy the matrix •2
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Osteogenesis- Bone Formation Derived from mesenchyme. Intramembranous ossification – formation of bone directly from connective tissue membranes. Endochondrial ossification – formation of bone from hyaline cartilage models. •3
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Intramembranous Ossification Forms the flat bones of the skull, mandible, & clavicles 1.Development of the ossification center 2.Calcification 3.Formation of trabeculae 4.Development of the periosteum & compact bone at the surface. •4
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Development of the Ossification Center Chemical signals mesenchymal cells osteogenic cells osteoblasts . Osteoblasts cluster in the Ossification Center & secrete the matrix of bone until it surrounds them. •5
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Calcification Secretion of matrix stops Trapped osteoblasts are now called osteocytes . Osteocytes lie in the lacunae & extend their cytoplasmic processes into the canaliculi . Ca2+ salts harden the matrix. •6
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As the extracellular matrix forms it develops into Trabeculae. Red Bone Marrow Forms
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This note was uploaded on 06/11/2009 for the course BIOL 10382 taught by Professor Brock during the Spring '09 term at Delgado CC.

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Appendix A- Bone Physiology Lecture Supplement.ppt - Bone...

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