Lecture 16 .pptx - Role of FGF10 in the induction and maintenance of the AER \u2022 FGF10 are critical not only for the induction but also for the

Lecture 16 .pptx - Role of FGF10 in the induction and...

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Role of AER and PZ in determining proximal-distal limb polarity Removal of the AER at various stages of limb development interrupts limb formation at various stages. If AER is removed early - only a humerus (most proximal part) forms If AER is removed later - humerus, ulna and radius form. Experiment 1:
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Experiment 2: A) When wing-bud PZ from young embryo was transplanted onto a old embryo’s wing bud (one that had humerus, ulna and radius already formed) extra set of early and intermediate structures (humerus, ulna and radius) is formed B) When old embryo’s wing-bud PZ was transplanted onto young embryo’s wing bud intermediate structures do not form Role of AER and PZ in determining proximal-distal limb polarity
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