Chapter 10 - Chapter 10: Regulation of Gene Expression in...

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Chapter 10: Regulation of Gene Expression in Bacteria and their Viruses I) Gene regulation A) Cells need to be able to recognize environmental conditions in which they should activate or repress transcription of relevant genes B) Cells need to be able to toggle on/off the transcription of each specific gene or group of genes C) Genetic switches control the efficient changes in gene expression in response to environmental conditions. This depends on two types of protein-DNA interactions 1) Promoter (determines where transcription begins) and RNA polymerase, must have promoter to be transcribed 2) Activators and repressors—DNA segments near promoter that service as binding sites for sequence-specific regulatory proteins that decides whether transcription will take place a) Most binding sites for repressors are called operators b) Positive regulation—presence of bound protein (activator) required for transcription allows for it to occur c) Negative regulation—absence of bound repressor allows transcription to
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This note was uploaded on 04/01/2008 for the course ZOL 341 taught by Professor Dworkin during the Spring '08 term at Michigan State University.

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Chapter 10 - Chapter 10: Regulation of Gene Expression in...

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