8.1 TLC Advil tablets.docx - Expt 8.1 Thin Layer Chromatography Christina McCool CHE210L Lab Section 13 November 1 2018 I Abstract The purpose of this

8.1 TLC Advil tablets.docx - Expt 8.1 Thin Layer...

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I. Abstract Expt. 8.1 Thin Layer Chromatography Christina McCool CHE210L Lab Section 13 November 1, 2018
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The purpose of this lab was to analyze analgesics tablets by using TLC to determine which analgesics contain and whether they can contain caffeine. Unknown #110 was found to be Excedrin because of the acetaminophen and caffeine present. The other common names involved were Bayer Aspirin, Tylenol, Motrin, Anacin, Excedrin and Vanquish. The Rf value for acetaminophen was found to be 0.418 and the Rf value for caffeine was found to be 0.091. The two Rf values for the unknown were found to be 0.18 and 0.472. II. Introduction 1. Briefly describe the process of Thin Layer Chromatography. Make it clear in the discussion what the stationary and mobile phases are and how they work together to effect the mobility of a substance in TLC. This is in general terms, not specifics for this lab. Chromatography is the separation of two or more compounds caused by their molecular interactions with two phases, a stationary and a moving phase. In a lab, cellulose paper is the stationary phase, and an ethanol mixture is the mobile phase. The samples are spotted near one edge of the paper, and this edge is dipped into the mobile stage. Capillary action is used to draw the solvent through the paper, and the molecules separate based on their interaction with the paper. One specific form of chromatography is thin layer chromatography. The stationary phase is normally a polar solid adsorbent. The network of these adsorbents creates
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