ANFS332 Lecture 3 Notes.docx - ANFS332 Lecture 3 Cell Death Clotting Strongylus vulgaris Inflammation Koch’s Postulates – IMPORTANT Four criteria

ANFS332 Lecture 3 Notes.docx - ANFS332 Lecture 3 Cell Death...

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ANFS332: Lecture 3 Cell Death, Clotting, Strongylus vulgaris , Inflammation Koch’s Postulates – IMPORTANT Four criteria designed to establish a causal relationship between a causative microbe and a disease. (Henle-Koch Postulates) 1. The microorganism must be found in abundance in all organisms suffering from the disease, (but not in healthy organisms). 2. The microorganism must be isolated from a diseased organism and grown in pure culture. 3. The cultured microorganism should cause disease when introduced into a healthy organism. 4. The microorganism must be re-isolated from the inoculated, diseased experimental host and identified as being identical to the original specific causative agent. Pathology Pathology is the study and diagnosis of disease through the examination of organs, tissues, cells, and bodily fluids The term encompasses both the medical specialty as well as the related scientific study of disease processes Disease can be considered as the presence of pathology Pathology does NOT have to mean INFECTION Gross Pathology Gross pathology refers to macroscopic manifestations of disease in organs, tissues, and body cavities The term is commonly used by anatomical pathologists to refer to diagnostically useful findings made during the gross examination of a surgical specimen or during a necropsy
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Diagram of a typical eukaryotic cell , showing subcellular components. Organelles: (1) nucleolus (2) nucleus (3) ribosome (4) vesicle (5) rough endoplasmic reticulum (ER) (6) Golgi apparatus (7) Cytoskeleton (8) smooth ER (9) mitochondria (10) vacuole (11) cytoplasm (12) lysosome THIS IS IMPORTANT Necrosis Necrosis refers to the death of cells and living tissue It begins with cell swelling, chromatin digestion , and disruption of the plasma membrane and organelle membranes Late necrosis is characterized by extensive DNA hydrolysis, vacuolation of the endoplasmic reticulum, organelle breakdown , and cell lysis .
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