Mutations - Mutations Mutations are heritable changes in nucleotide sequences of genetic material Mutations offer several advantages to organisms

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Mutations Mutations are heritable changes in nucleotide sequences of genetic material. Mutations offer several advantages to organisms. Mutations offer genetic diversity. For example, sickle cell malaria resistance is produced by a mutation to create a heterozygous allele which has a hybrid vigor. That is, because individuals with the sickle cell gene are less susceptible to malaria, it has not died out of the population. Mutations also allow the study of gene function. By comparing the wild type individual with a variant allele to a mutant, it may be possible to determine the function of that allele. There are also many biotechnology applications for mutants. E. coli can act as a host for synthesis of proteins if certain genes are introduced as mutant strains. The disadvantages to mutation should be fairly obvious. Mutations may disrupt gene function, which could potentially cause disease. Cancer is an example of disrupted gene function. Alterations to the genotype may be expressed in the phenotype, but mutantation in non-
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This note was uploaded on 04/01/2008 for the course MICRB 201 taught by Professor Sodeinde,olanrewa during the Fall '08 term at Pennsylvania State University, University Park.

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Mutations - Mutations Mutations are heritable changes in nucleotide sequences of genetic material Mutations offer several advantages to organisms

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