Transcriptional Regulation

Transcriptional Regulation - Transcriptional Regulation The...

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Transcriptional Regulation The main objective of the regulation of mRNA synthesis is to produce appropriate mRNA molecules that encode enzymes in response to changes in environment. This is a process of adaptation to the environment. While transcriptional regulation is slower than direct regulation of enzyme activity but it is more efficient. Housekeeping genes are those genes or proteins produced all the time; and these are said to be constitutively expressed. The lactose operon is a system often used to model transcriptional regulation. It is useful because it exhibits both positive and negative regulation. An operon is a gene or group of genes under the regulation of a single promoter (and its regulatory/operator sequences). Many genes are only expressed when they are needed. Each set of genes has a promoter which brings the RNA polymerase to initiate transcription; the promoter can also induce transcription (positive regulation) or inhibit transcription (negative regulation). Lactose, a disaccharide, may be broken down by beta-galactosidase into glucose and galactose, two monosaccharides. Glucose leads into metabolic pathways and galactose leads to
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This note was uploaded on 04/01/2008 for the course MICRB 201 taught by Professor Sodeinde,olanrewa during the Fall '08 term at Penn State.

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Transcriptional Regulation - Transcriptional Regulation The...

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