Translation - Translation - the conversion of mRNA Steps of...

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Translation - the conversion of mRNA Steps of Protein Synthesis: The first step in protein synthesis is the attachment of the amino acid to the tRNA at the 3’ acceptor arm. This activation process is catalyzed by aminoacyl-tRNA synthetases, which is a specific group of enzymes recognizes the correct tRNA and amino acid pairing and catalyzes that covalent peptide bond. The recognition is accomplished by the pairing of the tRNA anticodon triplet to its complementary mRNA codon triplet. This process usually occurs in the cytosol in bacteria and eukaryotes. The activation step is said to charge the tRNA molecules. The second step in the translation is initiation. In bacteria, initiation begins when the initiator methionine (tRNA-fMet) recognizes the AUG codon sequence on mRNA. The tRNA- fMet is specific for initiation; that is, there can be methionine amino acids throughout the sequence but they will use a different tRNA molecule. The recognition involves the interaction between the ribosome binding site and 16SrRNA; there is then the formation of a complex
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This note was uploaded on 04/01/2008 for the course MICRB 201 taught by Professor Sodeinde,olanrewa during the Fall '08 term at Pennsylvania State University, University Park.

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Translation - Translation - the conversion of mRNA Steps of...

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