HNF 150 - HNF 150 Notes 1 Roles of Lipoproteins a Transport...

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HNF 150 Notes 02/07/08 1. Roles of Lipoproteins a. Transport Triglycerides from Diet - Chlyomicron b. Transport Triglycerides from Liver - Very Low and Low Density Lipoprotein - Liver will synthesize triglycerides IF: 1. Eat too much carbohydrate 2. Increased levels of blood free fatty acids (from diet) 3. Consume alcohol 4. Increased insulin, decreased glucagon - Send to muscles and other tissues for energy or adipose for storage. - Liver - VLDL – LDL - Tissues c. Reverse Cholesterol Transport - High Density Lipoprotein - Tissues – LDL & HDL – Liver 1. Cardiovascular Disease a. Atherosclerosis i. The most common form of CVD ii. Characterized by plaques = soft fatty streaks on the inner walls of arteries, especially at the branch points. iii. “hardening of arteries” iv. Consequences 1. Aneurysm 2. Blood Clots
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a. Thrombus= stationary clot b. Thrombosis = stationary clot that has cut off the blood vessel c. Embolus = clot that breaks free and travels d. Embolism = when embolus become trapped in a smaller blood vessel.
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Unformatted text preview: (Heart Attack / Stroke) 2. How do vascular injuries happen? a. Possibilities: i. Bacterial or Viral Infection ii. Increased turbulence of blood flow at branch points iii. Irritants (smoking, drugs) iv. Hyperinsulinemia (Type II Diabetes or borderline diabetes) b. Results in Inflammation 3. How do our diet an physical activity affect heart disease a. I or D Blood LDL’s b. I or D Blood HDL’s c. I or D LDL oxidation d. I or D Blood Clotting e. I or D Blood Pressure f. I or D Inflammation g. I or D Obesity h. I or D Diabetes 4. Diet and Physical Activity in Relation to CVD a. Saturated fatty acids i. Decrease LDL receptors – Increase LDL circulating in blood. ii. Increase Inflammation b. Trans fatty acids c. Poly- and monounsaturated fatty acids i. Decrease LDL Levels ii. Neutral (or increase) HDL Levels iii. Decrease inflammation (particularly mono and omega-4 polyunsaturated fats)...
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