3310 Test 2 answer key.pdf - Multiple choice 1C 2B 3C 4C 5A...

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Multiple choice: 1C, 2B, 3C, 4C, 5A, 6C, 7D, 8B or D, 9B, 10B, 11B, 12C, 13C, 14B, 15D, 16C, 17D, 18B Short Answer 1. Need to demonstrate you know differences in bolus vs basal insulin, and what the consequence would be of injecting the wrong insulin. Bolus insulin has a peak (e.g. rapid acting insulin 1-2 h) and lasts a shorter time (3-5 h) than basal insulin (which would be no peak and last 20-24 h if Glargine). Thus, injecting bolus insulin at bedtime would cause hypoglycemia (low blood glucose <4 mM) in 1-2 h because there would be a greater amount of insulin acting within a shorter period of time than if basal insulin had been injected [ 1.5 marks ] When the blood glucose has gone too low, gluconeogenesis (in the liver) would become active to produce glucose and this would increase the blood glucose, however, due to a lack of insulin (after the 3-5 h) there would be less uptake of glucose into cells, thus, increasing the blood glucose more. [ 1.5 marks ] 2. Most of the fructose in the diet is taken up by the liver; fructose bypasses the first 2 steps of glycolysis, thus, it gets converted to Acetyl CoA [ 1 mark ] and if the TCA cycle does not need this Acetyl CoA, it is used to synthesize fatty acids; these fatty acids are added to a glycerol backbone to make triglycerides; if these triglycerides stay in the liver, there is fatty liver [ 1 mark ]. The liver can package the triglycerides into VLDL, and the VLDLs circulate in the blood resulting in hypertriglyceridemia. [
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