notes.docx - Plasma levels of AEA were found significantly enhanced in patients with AN or with binge eating disorder but not in women with

notes.docx - Plasma levels of AEA were found significantly...

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Plasma levels of AEA were found significantly enhanced in patients with AN or with binge eating disorder, but not in women with BN (Monteleone et al., 2005d). Frieling et al. (2009) reported higher blood levels of CB1 receptor mRNA in AN and BN patients as compared to healthy controls; however, patients with a disturbed impulse regulation exhibited lower CB1 receptor expression. Higher CB1 receptor expression was associated with lower scores in several eating disorder inventory-2 (EDI-2) subscales including perfectionism, impulse regulation and drive for thinness. A PET study demonstrated an increased number of CB1 receptors in the insula and inferior frontal and temporal cortex of underweight AN patients as well as in the insula of symptomatic BN subjects (Gérard et al., 2011). The dysregulated endocannabinoid tone of AN and BN patients may represent an adaptive response with the homeostatic aim of preserving energy balance by increasing hunger and hence food ingestion. Moreover, the altered endocannabinoid system may facilitate the rewarding
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  • Fall '19
  • Bulimia nervosa, Bulimic

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