BIO539 F18 06 Replication Assembly and Exit Notes.ppt - Viral replication assembly and exit Why do viruses replicate genome •We usually replicate our

BIO539 F18 06 Replication Assembly and Exit Notes.ppt -...

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Viral replication, assembly and exit
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Why do viruses replicate genome? We usually replicate our genome in order to undergo cell division. Viruses replicate their genome for two main reasons:
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General principles of viral replication In general, DNA is replicated to DNA, RNA is replicated to RNA Retroviruses: RNA copied to DNA, which is then copied to RNA. Pararetroviruses: DNA is copied to RNA, which is then reverse-transcribed into DNA.
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The replication strategy and the enzymes that carry it out depend on the genome type
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Where is the viral genome replicated? Cytoplasm Cytoplasm Nucleus Nucleus dsDNA dsDNA dsRNA dsRNA (+) ssRNA (+) ssRNA (-) ssRNA (not (-) ssRNA (not segmented) segmented) Retroviruses Retroviruses Pararetroviruses Pararetroviruses ssDNA viruses ssDNA viruses (-) ssRNA (segmented) (-) ssRNA (segmented)
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General principles of replication in eukaryotes
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Primers in virus replication Most RNA viruses do not need a primer.
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