kine 2011 lecture 3.docx - Glycolysis A chemical process involving 10 sequential reactions that break down glucose(6 carbon into 2 pyruvate(3 carbon

kine 2011 lecture 3.docx - Glycolysis A chemical process...

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Glycolysis A chemical process involving 10 sequential reactions that break down glucose (6 carbon) into 2 pyruvate (3 carbon) Some energy from the chemical bonds of glucose is used directly to convert ADP to ATP Numerous metabolic diseases affect glycolysis o McArdle disease: absence of enzyme involved in the first step of glycogen to glucose conversion Glycolysis is not efficient, only producing 2 ATP and 2 NADH per glucose (anaerobic) Most of the energy is still in the chemical bonds of pyruvate Pyruvate Decarboxylation Pyruvate enters mitochondrial matrix Catalyzed into acetyl-CoA (2 carbon) Acetyl-CoA enters the citric acid cycle Citric acid cycle 8 separate reactions directed by enzymes from the mitochondrial matrix 2 carbons are removed from the 6C citrate, converted to 4C oxaloacetate, to accept a acetyl-CoA 2 CO2, including the ones from pyruvate decarboxylation pass out the matrix, out of the cell to the blood
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