Trade Name: Tylenol Classification : Antipyretics, nonopiod analgesics Uses : PO: treatment of mild pain and fever IV: treatment of mild to moderate pain, moderate to severe pain with opioid analgesics, and fever Action : Inhibits synthesis of prostaglandins that may serve as mediators of pain and fever, primarily in CNS. Has no significant anti-inflammatory properties or GI toxicity Contraindications : Previous hypersensitivity, products containing alcohol, aspartame, saccharin, sugar or tartrazine should be avoided in pts who have hypersensitivity or intolerance in these compounds. Severe hepatic impairment/ active liver disease. Use cautiously in: OB: us in pregnancy only if clearly needed for IV Side effects : agitation, anxiety, headache, fatigue, insomnia, atelectasis, dyspnea, hypertension, hypotension, hepatotoxicity, constipation, nausea and vomiting, rash, urticaria Nursing implications : Assess amount, frequency and type of drugs taken in pts self medicating especially with OTC drugs. Assess for rash periodically during therapy. Assess fever, note presence of associated signs. Dosage : PO [Adults]: 325-650mg q 6hr or 1g 3-4x daily MAX: 3g or 2g/24hr in pts w. hepatic/renal impairment. [Infants] 10-15 mg/kg/dose q6hr PRN MAX: 5 doses/24 hr [Neonates] 10- 15mg/kg/dose q6-8hr PRN IV [Adults] 1000mg q6hr or 650 q4hr MAX 1000mg/dose 4g/day [Neonate] 12.5mg/kg q6hr MAX: 50mg/kg RECTAL [Neonate] 10-15 mg/kg/done q6-8hr PRN Interactions : Chronic high dose acetaminophen may increase bleeding with warfarin. Hepatotoxicity is additive with other hepatotoxic substances including alcohol. NSAIDs may increase the risk of adverse renal effects. Propranolol decreases the metabolism and may increase effects
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- Fall '19