Notes 2-13-08 - Psychoactive Drug A chemical substance that...

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Psychoactive Drug: A chemical substance that alters perceptions and mood - Continued use of a psychoactive drug produces tolerance . With repeated exposure to a drug, the drug’s effect lessens. Thus it takes greater quantities to get the desired effect. - Withdrawal: Upon stopping use of a drug (after addiction), users may experience the undesirable effects of withdrawal - Dependence : Absence of a drug may lead to a feeling of physical pain, intense craving (physical dependence) and (psychological dependence) - The biological basis of drug abuse and addiction o Nearly all abused and addictive drugs increase activity at the dopamine receptors in the brain o These drugs increase the release of dopamine, interfere with reuptake, and stimulate neurons that release dopamine or decrease activity of neurons that inhibit its release o Amphetamines increase sending of dopamine (ecstasy) o Cocaine blocks reuptake of dopamine & serotonin after their release - All addictive substances cause a change in dopamine functioning in the same general area of the brain - Dopamine is just one neurotransmitter - When you have a pleasurable experience, the brain releases dopamine - Drugs can fool the brain into being happy. It’s reliable.
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