CNS part 3 Chronic Neuro (1).pptx - NURS 761 Central Nervous System Drugs Drugs for Chronic Neurologic Conditions \u2013 Part 3 Parkinson\u2019s Alzheimer\u2019s

CNS part 3 Chronic Neuro (1).pptx - NURS 761 Central...

This preview shows page 1 - 8 out of 20 pages.

NURS 761PharmacotherapeuticsCentral Nervous System DrugsDrugs for Chronic Neurologic Conditions – Part 3Parkinson’s, Alzheimer’s, Multiple Sclerosis, Seizure DisordersFall 2018Faculty: Dr. Cheryl OetjenDr. Carol Urban
Background image
Learning Objectives1.Identify the action and pharmacologic action of drugs used for chronic neurologic conditions.2.Describe the clinical indications for drugs used for chronic neurologic conditions. 3.Identify patients who are at increased risk for negative outcomes of pharmacotherapeutics with drugs used for chronic neurologic conditions.4.Develop a teaching plan to ensure optimal patient outcomes.
Background image
Drugs to KnowDrugs for Parkinson’sDopamine replacement: levodopa, levodopa-carbidopaDopamine agonists: pramipexole, apomorphine, ropinirole, bromocriptineMiscellaneous: amantadine, selegiline, entacaponeAnticholinergics: benztropine, trihexyphenidylDrugs for Seizure Disordersphenytoin, fosphenytoin, carbamazepine, oxcarbazepine, ethosuximide, valproic acid, levetiracetam, gabapentin, pregabalin
Background image
Drugs for Alzheimer’sdonepezil, galantamine, rivastigmineDrugs for Multiple Sclerosisinterferon beta 1-b, glatiramer
Background image
Parkinson’s: MOA & Clinical UseParkinson’s disease occurs as dopamine is no longer produced in substantia nigra; symptoms don’t usually occur until 80% or more of dopamine is lost
Background image
Dopamine and ACh held in “balance” and loss of dopamine allows ACh to predominate; symptoms of Parkinson’s are often due to this imbalance: dopamine-related motor difficulty (bradykinesia, “pill-rolling” tremors, “cogwheel rigidity”) and cholinergic S/S (SLUDGE)
Background image
Goal of treatment is to slow progression of disease and limit effect on ADLs; dopamine enhancers (agonists), replacement and anticholinergic main drugs usedAll patients will eventually need replacement therapy. Levodopa combined with carbidopa used
Background image
Image of page 8

  • Left Quote Icon

    Student Picture

  • Left Quote Icon

    Student Picture

  • Left Quote Icon

    Student Picture