PJ-11-5-11[469] (3).pdf - Pharmacogn J 2019 11(5 A...

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Pharmacognosy Journal, Vol 11, Issue 5, Sep-Oct, 2019 1 Original Article Pharmacogn J. 2019; 11(5): A Multifaceted Journal in the field of Natural Products and Pharmacognosy Cite this article: Palomino-De-La-Gala R, Justil-Guerrero H, Arroyo-Acevedo J, Rojas-Armas J, Aguilar-Carranza C, Martínez-Heredia J, et al . Protective Effect of the Ethanolic Extracts of Leaves of Chuquiraga spinosa Less and Baccharis genistelloides on Benign Prostatic Hyperplasia in Rats. Pharmacog J. 2019;11(5): Phcogj.com Protective Effect of the Ethanolic Extracts of Leaves of Chuquiraga spinosa Less and Baccharis genistelloides on Benign Prostatic Hyperplasia in Rats Robert Palomino-De-La-Gala 1,2 , Hugo Justil-Guerrero 1,2 , Jorge Arroyo-Acevedo 1,2 , Juan Rojas-Armas 1,2 , Cristian Aguilar-Carranza 3 , Jaime Martínez-Heredia 1,2 , Edwin Cieza-Macedo 1,2 , Carlos García-Bustamante 1,2 , Oscar Herrera-Calderon 4 , Edwin Enciso-Roca 5 , Roberto Chávez- Asmat 6 , Lester Dominguez-Huarcaya 7 INTRODUCTION Benign prostatic hyperplasia (BPH) is one of the most common conditions affecting middle-aged men. Since 2003, an increase in global prevalence has been reported, currently affecting around 1.1 billion individuals. Up to 25% of men aged 50 to 65 years have lower urinary tract symptoms such as nocturia, urgency, frequency, a feeling of not completely emptying the bladder, effort to urinate and weak urinary flow these discomforts can significantly affect the quality of life. The costs of BPH treatments are based on direct costs (medications, procedures, images, medical consultations), indirect costs (loss of income) and intangibles (pain and suffering). 1,2 The most effective pharmacological treatments for BPH with symptoms of the lower urinary tract include alpha-1 adrenergic blockers and 5-alpha reductase inhibitors. Perhaps, up to 30% of patients do not achieve a sufficient improvement of symptoms with medication and have adverse effects such as rhinitis, orthostatic hypotension, headache, iris prolapse, retrograde ejaculation, livid reduction, erectile dysfunction and gynecomastia; In addition to the high cost of treatments, the idea has been reinforced towards the search and use of "safer" plant extracts. 3,4 Chuquiraga and Baccharis are a large genus of the Asteraceae family with more than 500 species 3 widely distributed in America, but with greater diversity in the Andes. Chuquiraga spinosa Less (ChS) is an herbaceous plant widespread in the western Andes of Peru, between 3000 and 4500 m altitude, it is used in folk medicine for the treatment of inflammatory diseases (mainly against prostatic diseases). 5 The phytochemical studies of Chuquiraga spinosa Less have revealed that it contains 9 types of flavonoids (quercetin-3-O-glucuronide, quercetin-3- O-rutinoside, quercetin-3-O-glucoside, kaemperol- 3-O-glucuronide, kaemperol-3-O-rutinoside, kaempherol-3-O-glucoside, isorhamnetin-3-O- glucuronide, isorhamnetin-3-O-rutinoside and isorhamnetin-3-O-glucoside) and a phenolic compound (p-hydroxyacetophenone), flavonoids ABSTRACT Introduction:
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