Week 4 Discussion (2).pptx - BIPN 152 WEEK 4 Section A08 6PM – 6:50PM Discussion Agenda Group Presentatio n Lecture Review Neuro 3L Sign-Ups Sarah

Week 4 Discussion (2).pptx - BIPN 152 WEEK 4 Section A08...

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BIPN 152: WEEK 4 Section A08: 6PM – 6:50PM
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Discussion Agenda Group Presentatio n Lecture Review Neuro 3L Sign-Ups
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GROUP PRESENTATION Sarah Sofeso Jiayuan Murphy Cynthia Sanchez Andrea Fernandez Umu Rogers Please pass your Journal Club assignments to the front!
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LECTURE REVIEW
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Tri-Synaptic Prime Circuit Major hippocampal circuit (3 synapses) Dark purple = cell bodies Light purple = dendrites NT = glutamate in all synapses (+) Granule neurons : cell bodies have smallest diameter in brain Region with granule neurons = dentate gyrus Receive signals from neurons in the entorhinal cortex (synapse #1) Axons of granule neurons come together to form mossy fibers (wispy)
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Tri-Synaptic Prime Circuit Granule neurons synapse onto CA3 pyramidal neurons (apical side) Apical dendrites : emerge from pyramid apex, longer Basal dendrites: emerge from pyramid base, shorter Synapse #2 CA3 pyramidal neurons send axons to CA1 pyramidal neurons through Schaffer collateral commissural pathways Synapse #3
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Long-Term Potentiation Experiment: Single current pulse to granule neurons: reproducible amplitude Tetanic stimulation (many APs in short time): amplitude of response increases Aka potentiated response
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Key Ideas 1). LTP is associated with growth
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