Peter_Osseward_talk_6_6_2019.pptx - Characterizing spinal cord neurons through genetics Healthy Diseased Brain mini-lectures Peter Osseward Pfaff Lab

Peter_Osseward_talk_6_6_2019.pptx - Characterizing spinal...

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Characterizing spinal cord neurons through genetics Healthy & Diseased Brain mini-lectures 6/6/2019 Peter Osseward Pfaff Lab
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Characterizing Neuronal Diversity Cortical Layers Spinal Cord Laminae Neuron location, morphology, neurotransmitter (glutamate, gaba, dopamine, acetylcholine), connectivity, etc. Motor Neurons Motor Neurons
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Neuron Types - Genetics Genetic cell types often correspond to other interesting neuronal features (location, neurotransmitter, connectivity, etc.) Use genetic tools to manipulate genes and cell types (knockouts, optogenetics) Chat (Choline O-Acetyltransferase) Cortical Layers Spinal Cord
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Outline Question – How are spinal interneurons genetically organized? Approach – Use single cell RNA sequencing to unbiasedly measure gene expression in many spinal cord neurons Question – What are the neuronal characteristics that relate to our genetic categories of spinal neurons?
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