Recrystallization Lab Manual - Fall 2019 - CHEM-212-002:003:004:005:006:007:009:012 & CHEM 224-001 3 - SF Recrystalliza!on Lab Manual

Recrystallization Lab Manual - Fall 2019 - CHEM-212-002:003:004:005:006:007:009:012 & CHEM 224-001 3

This preview shows page 1 - 3 out of 6 pages.

Recrystalliza ! on Lab Manual Recrystallization (Solo Lab) Background Reading Introduction Analgesics, often referred to as "pain killers", are drugs that reduce minor pains such as headaches. Aspirin, whose active component is acetylsalicylic acid (ASA), is the most widely sold analgesic. It is also an antipyretic drug (reduces fever), an anticlotting agent, and an anti-inflammatory agent. Acetaminophen, found in Tylenol, is a very popular aspirin alternative. It is an analgesic as well as a mild antipyretic. Techniques to review: Weights and Measures Recrystallization Filtration Melting Point !! !! SF
Image of page 1

Subscribe to view the full document.

Figure 1 - Structures of some popular NSAIDs. In this experiment, you will synthesize acetaminophen (Tylenol) from p-aminophenol (refer to Scheme 1). The acetaminophen you make will be impure and will thus require purification. To obtain pure acetaminophen from your crude product, you will use recrystallization, a commonly used method for the purification of solid products. Synthesis of acetaminophen from p-aminophenol. Trace impurities can drastically impact the properties of a compound, which is why methods for purification are so important, especially in the pharmaceutical industry. Solids can be purified by recrystallization because impurities often have very di ff erent solubility properties than the desired solid. The breaking down of the impure solid material by dissolution and subsequent reformation of its crystal lattice leaves the impurity dissolved in the solution and the purified material as a crystalline solid. The technique of recrystallization involves the dissolution of the material to be crystallized in a hot solvent, followed by slow cooling of the solution. The desired material has a decreased solubility in the chosen solvent at lower temperatures, and will solidify from the solution on cooling. This process is called crystallization if the crystal growth is relatively slow and selective. If the process is fast and non- selective, it is called precipitation. During the latter, the crystal lattice forms rapidly
Image of page 2
Image of page 3
  • Fall '17
  • david

What students are saying

  • Left Quote Icon

    As a current student on this bumpy collegiate pathway, I stumbled upon Course Hero, where I can find study resources for nearly all my courses, get online help from tutors 24/7, and even share my old projects, papers, and lecture notes with other students.

    Student Picture

    Kiran Temple University Fox School of Business ‘17, Course Hero Intern

  • Left Quote Icon

    I cannot even describe how much Course Hero helped me this summer. It’s truly become something I can always rely on and help me. In the end, I was not only able to survive summer classes, but I was able to thrive thanks to Course Hero.

    Student Picture

    Dana University of Pennsylvania ‘17, Course Hero Intern

  • Left Quote Icon

    The ability to access any university’s resources through Course Hero proved invaluable in my case. I was behind on Tulane coursework and actually used UCLA’s materials to help me move forward and get everything together on time.

    Student Picture

    Jill Tulane University ‘16, Course Hero Intern

Ask Expert Tutors You can ask 0 bonus questions You can ask 0 questions (0 expire soon) You can ask 0 questions (will expire )
Answers in as fast as 15 minutes