Exam III Study Guide(2).docx - Exam III Study Guide 1 Start...

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Exam III Study Guide 1.Start preparing a table to be completed for allthe classes of anti-infectives. Include:a.the names of each main drug class as well as a prototypes and important related drugsb.whether and for what infections and infectious organisms they are considered first-line (i.e., aerobic versus anaerobic, gram positive versus gram negative, etc.)c.whether they are bacteriostatic or bactericidald.specific and important contraindicationse.the relative degree to which resistance develops and a general mechanism by which resistance occursf.general risk for allergic reactions and whether antibiotics in other classes may cross-react to trigger allergic responsesg.what are foods to avoid with each class of anti-infectivesh.any specific host toxicities.2.Describe the basic mechanism of action of the penicillins. 3.Compare and contrast gram-positive and gram-negative bacteria. What penicillins can penetrate the outer membrane of gram-negative bacteria? 4.Explain the beta-lactam ring and explain why penicillins are part of the family of antibiotics called the beta-lactam antibiotics, and how that relates to the vulnerability of these antibiotic classes to inactivation by certain bacteria. List alternative antibiotic therapies for the treatment of resistant bacteria (MRSA, VRE).5.State the four main classes of penicillins:a.narrow-spectrum penicillins that are penicillinase sensitiveb.

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