Owen_Melissa_Rec6.docx - BIO 340 Fall 18 Recitation 6 Name_Melissa Owen Recitation 6 short-answer assignment Cystic fibrosis is an autosomal recessive

Owen_Melissa_Rec6.docx - BIO 340 Fall 18 Recitation 6...

This preview shows page 1 - 2 out of 3 pages.

BIO 340 Fall 18 Recitation 6 Name: ___Melissa Owen__________________________ Recitation 6 short-answer assignment Cystic fibrosis is an autosomal recessive disorder caused by a loss-of-function mutation in a chlorine channel, which causes a thickening of the mucus, leading to respiratory failure. This disease affects approximately 1 in 1353 newborns in the Republic of Ireland every year. Fill in the following values (1 points each): recessive is q P+q=1 q = q^2 = 1/1353 = 0.00074 (0.00074)^1/2 = .027 p = (1-q) =.97 1-.027 = 0.973 Current population of Ireland is approximately 4.8 million. Based on the allele frequencies that you calculated, what is the expected number of cystic fibrosis carriers (heterozygotes) in Ireland? Show your work. (1 point) (2pq) = 2(.027)(.973) = .0525 x 480,000,000 = 25 million 2pq = 2 * .027 * .973 = .05254= 5.25% are heterozygous (Cc) Unaffected (Heterozygous Cc) = 2pq x total population = 0.05254 x 4.8 million = 0.252 million Affected (homozygous cc) q^2 x total population = 0.00074 x 4.8 million = 0.003552 million Unaffected (homozygous dominant CC) p^2 x total population = 0.9467 x 4.8 million = 4.544 million What is the expected number of healthy individuals in the population? Show your work. (1 point)
Image of page 1

Subscribe to view the full document.

Image of page 2
  • Summer '19

What students are saying

  • Left Quote Icon

    As a current student on this bumpy collegiate pathway, I stumbled upon Course Hero, where I can find study resources for nearly all my courses, get online help from tutors 24/7, and even share my old projects, papers, and lecture notes with other students.

    Student Picture

    Kiran Temple University Fox School of Business ‘17, Course Hero Intern

  • Left Quote Icon

    I cannot even describe how much Course Hero helped me this summer. It’s truly become something I can always rely on and help me. In the end, I was not only able to survive summer classes, but I was able to thrive thanks to Course Hero.

    Student Picture

    Dana University of Pennsylvania ‘17, Course Hero Intern

  • Left Quote Icon

    The ability to access any university’s resources through Course Hero proved invaluable in my case. I was behind on Tulane coursework and actually used UCLA’s materials to help me move forward and get everything together on time.

    Student Picture

    Jill Tulane University ‘16, Course Hero Intern

Ask Expert Tutors You can ask 0 bonus questions You can ask 0 questions (0 expire soon) You can ask 0 questions (will expire )
Answers in as fast as 15 minutes