Health and Illness 1 SLE notes.docx - Systemic Lupus Erythematosus(SLE Multisystem inflammatory autoimmune disease Complex multifactorial disorder

Health and Illness 1 SLE notes.docx - Systemic Lupus...

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Systemic Lupus Erythematosus (SLE) Multisystem inflammatory autoimmune disease Complex multifactorial disorder: genetic, hormonal, environmental, immunologic Marked by an unpredictable course with alternating periods of remission and worsening disease Most cases in women of childbearing years More common in African Americans, Asian Americans, Hispanics, and Native Americans than in whites Affects Skin Joints Serous membranes (Pleura, Pericardium) Renal system Hematologic system Neurologic system Etiology and Pathophysiology Etiology unknown Probably causes: genetic influence, hormones, environmental factors, certain medications Overaggressive autoimmune reactions directed against constituents of cell nucleus, single and double-stranded DNA, activation of B and T cells Clinical Manifestations
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Severity of SLE is variable. Ranges from relatively mild to rapidly progressive affecting many body systems
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