Health and Illness 1 Lymphoma notes.docx - Lymphoma Malignant neoplasm Originate in bone marrow and lymphatic structures Causes proliferation of

Health and Illness 1 Lymphoma notes.docx - Lymphoma...

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Lymphoma Malignant neoplasm Originate in bone marrow and lymphatic structures Causes proliferation of lymphocytes Constitutes 4% of all cancers in US Two types: Hodgkin’s lymphoma, Non-Hodgkin’s lymphoma Hodgkin’s Lymphoma v Non-Hodgkin’s Lymphoma Hodgkin’s lymphoma: Cellular origin in B lymphocytes. Extent of disease is localized to regional by may be more widespread. B symptoms (fever, night sweats, weight loss) are common to rare Non-Hodgkin’s Lymphoma: Cellular origin in B lymphocytes (88%), T or natural killer lymphocytes (12%). Extent of disease is disseminated. B symptoms are uncommon to common Hodgkin’s Lymphoma 11% of all lymphomas Characterized by proliferation of abnormal, giant, multinucleated cells Bi-modal age specific incidence. 15-30 years. Adults above 55 years Twice as prevalent in men as in women Long-term survival exceeds 80% for all stages Unknown cause Key factors in development: Epstein-Barr viral infection (EBV), genetic predisposition, exposure occupational toxins, increased incidence with HIV infections
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Pathophysiology of Hodgkin’s Lymphoma Normal lymph node structure destroyed by hyperplasia of monocytes and macrophages Arises in a single location (80% cervical lymph nodes) then spreads to adjacent lymphatics
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