Altered Immune Responses and Transplantation (Immunity)Definition: Normal physiologic response to microorganisms and proteins as well as conditions associated with an inadequate or excessive immune responseAltered ImmunityConditions where immune responses are suppressed or exaggeratedSuppressed responses: immunocompromised or immunodeficiencyExaggerated responses: hypersensitiveNormal Immune ResponseImmunity: body’s ability to resist diseaseServes 3 functions: defense, homeostasis, surveillanceDefenseBody protects against invasion by microorganisms. Prevents development of infection by attacking foreign antigens and pathogensHomeostasisDamaged cellular substances digested and removed. Body’s different cell types remain uniform and unchangedSurveillanceMutations continually occur in body but are normally recognized as foreign cells and destroyedTypes of Immunity
Innate: present at birth, 1stline of defense. Neutrophils and Monocytes primary WBCs. Acquired: developed immunity. Active, passive.Normal Immune ResponseAntigens: substances the body recognizes as foreign that elicit an immune response. Mostcomposed of protein.Antibodies: Immune globulins produced by lymphocytes in response to antigensOrgans of Immune SystemTonsils, Lymph nodes, Thymus gland, Bone marrow, Bronchial-associated lymph tissue, Skin-associated lymph tissue, Spleen, Gut-associated lymph tissue, Genital-associated lymph tissueLymphoid Organs- Central (primary)Thymus gland: shrinks with age, involved in differentiation and maturation of T lymphocytesBone marrow: produces RBCs, WBCs, platelets.
- Fall '19
- Kathy Knobloch