18. Suppose you are constructing a human genomic li- brary in BAC vec.docx

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18. Suppose you are constructing a human genomic li- brary in BAC vectors where the human DNA frag- ments are on average 100,000 bp. a. What is the minimum number of different recom- binant BACS you a greater than zero chance of having a complete library-meaning one in which the entire is represented? The simple statistical equation that follows allows you to determine the size that a genomic library needs to be (that is, the number of independent recombinant need to construct in order to have genome need to make) for a given likelihood that clones you the entire genome is represented in the library. In (1 - P) N= In (1 -f) In the equation, N is the number of independent recom- binant clones; P is the probability that any particular part of the genome is represented at least one time; f is the fraction of the genome in a single recombinant clone. (Note: In is the natural log, sometimes written as l b. Calculate ffor
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