Project.docx - Plaquenil(Hydroxychloroquine sulfate 1 Generic Name Hydroxychloroquine sulfate 2 Brand Name Plaquenil 3 Group Anti protozoal drug 4

Project.docx - Plaquenil(Hydroxychloroquine sulfate 1...

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Plaquenil ( Hydroxychloroquine sulfate) 1. Generic Name: Hydroxychloroquine sulfate 2. Brand Name: Plaquenil 3. Group: Anti protozoal drug 4. Specific Group: Anti-malarial drug ( chemical group: Quinolines) 5. Mechanism of Action: Hydroxychloroquine binds to DNA, interfering with protein synthesis. It also inhibits DNA and RNA polymerases. It’s active against asexual erythrocytic forms of Plasmodium malariae, P. ovale, P. vivax, and many strains of P. falciparum. 6. Indication for use: PLAQUENIL is indicated for the suppressive treatment and treatment of acute attacks of malaria due to Plasmodium vivax, P. malariae, P. ovale, and susceptible strains of P. falciparum (Can’t be used in chloroquine resistant malaria). This medication is also used, usually with other medications , to treat certain auto-immune diseases like lupus , rheumatoid arthritis. This medication is also used in the treatment of certain infections like endocarditis and Q fever. 7. Contraindication: Use of this drug is contraindicated in the presence of retinal or visual field changes attributable to any 4-aminoquinoline compound, in patients with known hypersensitivity to 4-aminoquinoline compounds, and for long-term therapy in children 8. Dosage: Adults :For acute treatment, 800 mg PO, then 400 mg PO 6-8 hours later, then 400 mg PO at 24 and 48 hours. For prophylaxis, 400 mg PO weekly, starting 2 weeks before exposure and continued for 4 weeks.
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Children: For Acute treatment, 3 mg/kg base PO, not to exceed 400 mg/day base. For prophylaxis, 6.5 mg/kg base (not to exceed 400 mg [310 mg base]) PO weekly, starting 2 weeks before exposure and continued for 4 weeks. 9. Route of Administration: oral Tablets 10. Adverse Reactions: GI distress, visual disturbances, retinopathy, vertigo, tinnitus, and nerve deafness. 11. Side effects: Nausea , stomach cramps , loss of appetite, diarrhea , dizziness , or headache.
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Flagyl (Metronidazole): 1. Generic Name: Metronidazole 2. Brand Name: Flagyl 3. Group: Anti biotic and Anti-microbial Drug, 4. Specific Group: Anti protozoal drug (Tissue amoebicides) 5. Mechanism of Action: Metronidazole binds to DNA and causes strand breakage. In addition, it acts as an electron acceptor for flavoproteins and ferredoxins. Metronidazole
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