Exam 4 F2018 Ethan Fletcer.pdf - Ethan Fletcher Oncology F2018 Exam#4 Critical Thinking Due by 12 am/midnight on Wednesday as an PDF document directly

Exam 4 F2018 Ethan Fletcer.pdf - Ethan Fletcher Oncology...

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1 Ethan Fletcher Oncology F2018 Exam #4 Critical Thinking Due by 12 am/midnight on Wednesday 11/27/18 as an PDF document directly attached to an email sent to [email protected] Instructions: This exam is due by 12 am-midnight. That means it must reach my email inbox by this time. Late exams will be reduced by 25% each day it is late. You must type write your answers and turn them into me electronically via email. This means email me your PDF document. I cannot open google docs, so make sure that you email it to me as an attached PDF. Make sure to add yourself to the “send to” section, this way you can guarantee that you attached your exam. MAKE SURE TO THINK ABOUT THE QUESTION THEN ANSWER IN A CLEAR, CONCISE AND COMPLETE MANNER. You will be scored on your level of critical thinking and how you use that to answer the questions. This is an upper division cell molecular course, therefore use the terminology folks and cellular mechanisms involved- DON’T be overly general . You MUST reduce your answers to no more than ½ page per question . (Times New Roman, 12pt, single spaced. 1.Select one answer and explain/support why that is the best answer compared to the others. Human cancer cells that lack telomerase activity… a.Be in crisis b.Have shorter telomeric repeats c.Demonstrate the exchange of sequence information between telomeres through unequal crossing over. d.Undergo chromosomal translocations. e.All of the above. Answer E is the most correct answer. In a cell, telomerase maintains the telomeres which protect the ends of chromosomes. When cells divide, the telomeres become shorter over time. Thus, eventually they will degrade and DNA will be lost. However, if telomerase is expressed in high amounts, a cell can replicate endlessly. When a cell lacks telomerase activity, all of the above statements would be true. When telomeres shorten to the point at which the DNA cannot perform its function, thus resulting in BFB cycles and chromosomal translocations. Telomeric repeats would also be shorter, as telomerase is not active and able to restore the length of these telomeres. Telomerase allows cells to avoid crisis because it destabilizes the operations of the generational clock. 2.Select one answer and explain/support why that is the best answer compared to the others. Breakagefusionbridge (BFB) cycles may help drive tumorigenesis by
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2 In cells going through BFB, breaking of the chromosome allows cancer cells to acquire mutated alleles that result from the breaking process. Cells undergoing BFB may survive if p53 is not functioning, and the surviving cells may have the knowledge on how to proliferate and maintain their telomeres. The pre-malignant cells can now utilize a lot of advantageous genotypes. While these BFB cycles do not necessarily directly lead to an
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  • Fall '18
  • Sylvia Vetrone

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