Ras Signaling Myeloma Assignment.docx - DUE Tues as a typewritten hard copy single spaced Primary Literature Article Pan-Raf co-operates with

Ras Signaling Myeloma Assignment.docx - DUE Tues as a...

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DUE: Tues 10/9/18 as a typewritten hard copy- single spaced. Primary Literature Article: Pan-Raf co-operates with PI3K-dependent signaling and critically contributes to myeloma cell survival independently of mutated RAS Introduction/Background Why is MM important, and what are the most common mutations in this cancer? o MM is a cancer of plasma cells. Most common mutations affect N and K-RAS. This leads to RAS- Dependent signaling What had this group already discovered and what did it suggest? o Depletion of oncogenic RAS induces apoptosis in MM cells, which leads us to believe mutant RAS still contributes to cancer cell survival even in fully developed MM Why does Ras signaling need to be inhibited in MM? o Because Ras contributes to cell survival in MM, as shown in their previous research. (Above) What is the role of the Raf kinase complex in MM and why is it important? o The Raf kinase complex uses the A, B, and C Raf isoforms to mediate RAS- Dependent signaling. o Activating mutations of the B-Raf isoform are common in certain cancer entities. In melanoma, treatment with B-Ref inhibitors led to improved survival in patients with B-Ref mutated melanoma. What is the purpose of the study? o The purpose of this study is to further investigate the role of Raf in MM and assess its role as a signaling hub, which may be leading to aberrant signaling.
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  • Fall '18
  • Sylvia Vetrone

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