Biochemistry Homework 1.docx - Questions start on the next page 1 As will be seen in succeeding chapters enzymes provide a specific binding site for

Biochemistry Homework 1.docx - Questions start on the next...

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Questions start on the next page. 1. As will be seen in succeeding chapters, enzymes provide a specific binding site for substrates where one or more chemical steps can be carried out. Often these sites are designed to exclude water. Suppose that at a binding site, a negatively charged substrate interacts with a positively charged atom of an enzyme. a. Using Coulomb’s equation, explain how the presence of water might affect the interaction. What sort of environment might be preferable for an ionic interaction? Note that a numerical answer is not required here. A. Coulomb’s equation measures the force of attraction between charges. Water is very polar, which grants it a charge it can use to disrupt other charged interactions. This is shown in its very high dielectric constant which measures its ability to be polarized by an electric field. Force of attraction is inversely proportional to dielectric constant. A nonpolar environment would be preferable because it contains less charge, granting it a lower dielectric constant. b. How would an ionic interaction be affected by the distance between the oppositely charged atoms? A. Further distances would decrease the force, since it would make the denominator of the Coulomb equation larger. As force decreases, charge will also decrease according to the equation, therefore ionic interactions would be weakened with increased distance. 2. Proteins are built from a repertoire of 20 amino acids. Examine the four amino acids given below:
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  • Spring '14
  • DevinS.Iimoto

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