Talk-Univ Hong Kong#2B-Oct2018-Student Set (2).pdf - Endocrine Disruptor Activities in Reproductive Toxicity National Institute of Environmental Health

Talk-Univ Hong Kong#2B-Oct2018-Student Set (2).pdf -...

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National Institute of Environmental Health Sciences National Institutes of Health Endocrine Disruptor Activities in Reproductive Toxicity
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Cell Mechanisms of Hormone Action 1. Rapid Action with Membrane Receptors (ER α ) (G- Protein – GPR30 ) – Early fast responses (minutes) 2. Nuclear Receptor ER α Ligand-dependent Action - DNA Binding activates gene responses (Late actions occur over hours/days) 3. Nuclear Receptor ER β Ligand-dependent Action DNA Binding activates gene responses (Late actions occur over hours/days) 4. Nuclear Receptor ER α Ligand-Independent Action DNA Binding activates gene responses (Actions occur over hours/days)
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