Final.pdf - BIOL105 Final Winter 2019 Name ID Discussion Section Day/Time READ THIS FIRST • Please fill in the requested information in the section

Final.pdf - BIOL105 Final Winter 2019 Name ID Discussion...

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BIOL105 Final Winter, 2019 Name: ____________________________________ ID #: ____________________________________ Discussion Section Day/Time: ____________________________________ READ THIS FIRST Please fill in the requested information in the section above. Read each question through COMPLETELY and CAREFULLY TWICE before starting to answer it. Write legibly. You may work through problems and give your answers in pencil or pen. Completely erase or scratch out anything that you have corrected or replaced. Most questions have a BOX provided for the final answer. That is where we will look for the answer you want graded. Use CORRECT genetic nomenclature, including "/" and ";" symbols where appropriate. You may use "-" to indicate any allele. maximum points Q1: 6 Q2: 12 Q3: 7 Q4: 15 Q5: 4 Q6: 5 Q7: 12 Q8: 10 Q9: 5 Q10: 11 Q11: 5 Q12: 10 Q13: 6 Q14: 9 Q15: 12 Q16: 7 Q17: 4 Total: 140
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Question 1 ) (6 points) For the questions below, ignore the effects of recombination. a) From a D/d; E/E; F/f; G/g male mouse, how many different genotypes of sperm will be produced by a single starting germ cell? b) From test crosses between D/d; E/E; F/f; G/g mice and tester mice, how many different genotypes of offspring will be produced? c) From crossing D/d; E/E; F/f; G/g mice with each other, how many different genotypes of offspring will be produced? Question 2 ) (12 points) Cancer cells display mutations in numerous types of genes, as listed in the table below. Whether the genes are haplo-sufficient or haplo-insufficient is indicated in the 2 nd column. In the 3 rd -6 th columns, indicate with an X the genotype you would expect to see in cancer cells. Choose only 1 genotype in each row. + means wild-type allele lf means loss-of-function allele gf means gain-of-function allele Function of normal gene Haplo-sufficient or insufficient? +/+ lf/+ lf/lf gf/+ Promotes mitosis and cell proliferation Haplo-sufficient Promotes mitosis and cell proliferation Haplo-insufficient Keeps cells in G0 or G1 Haplo-sufficient Keeps cells in G0 or G1 Haplo-insufficient Promotes programmed cell death (apoptosis) Haplo-sufficient Inhibits programmed cell death (apoptosis) Haplo-sufficient Question 3) (7 points) In a male heterozygous for an albino mutation on chromosome 2, nondisjunction of the X and Y chromosomes occurred in meiosis I. Correctly write the genotypes of the 4 resulting sperm, using the notations X, Y, A, and a. CIRCLE 1 of the sperm above that when united with a normal egg would produce an XO offspring. What sex would an XO be in a human? What sex would an XO be in a fruit fly?
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Question 4) (15 points) The diagram below shows the positions of 4 genes (A, D, G, H) on chromosomes 9 and 11 in yeast. Mutations make yeast unable to synthesize alanine. Fill in the complementation test results and the mapping results that would have led to the gene and allele assignments below. You can assume that all genes are haplo-sufficient, and all mutations are loss-of-function.
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