njc26_publication_3.DOC - � المجلد الثاني والربعون‬2011-‫المجلة العراقية الوطنية لعلوم

njc26_publication_3.DOC - � المجلد الثاني...

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- ءايميكلا مولعل ةينطولا ةيقارعلا ةلجملا 2011 نوعبرلاو يناثلا دلجملا Iraqi National Journal of Chemistry,2011,volume 42,283-298 Evaluation of Serum Cholinesterase Activity, Lipid Peroxidation and Lipids Profile in Type 2 Diabetes Mellitus Abdulkareem Mohammed Jewad, Oda M. Yasser and Science College, Basrah University Science College, Babylon University Nadhum Abdel Nabi Awad Science College, Basrah University (NJC) (Recevied on 27/6/2010) (Accepted for publication 2/5/2011) Abstract The study was designed to evaluate serum cholinesterase activity, lipid peroxidation, lipids profile and nitric oxide production, in sera of diabetes type 2 and the control group to show whether there are changes in their levels. The results of this study showed significant elevations (P< 0.001) in each of serum cholinesterase and lipid peroxidation end product represented by serum MDA concentrations in type 2 diabetic patients as compared to control group. Although, this study showed a non-significant elevation in serum nitrite, the nitrate was elevated significantly (P< 0.001) in diabetic type 2 patients as compared to control group. The lipids profile of diabetic type 2 patients showed significant changes represented by significant elevations (P< 0.001) in each of TG, t. cholesterol, LDL and VLDL, and a significant decrease (P< 0.001) in HDL as compared to control group. Using regression analysis showed a significant positive correlation between serum cholinesterase (P< 0.001) and each of FBS (r = 0.698), MDA (r = 0.69), NO x (r = 0.51), t. cholesterol (r = 0.487), TG (r = 0.691), LDL (r = 0.575), and VLDL (r = 0.455), and a significant negative correlation(P< 0.001) with HDL (r = - 0.861). Conclusion can be made that diabetes mellitus is a low grade systematic inflammation associated with high oxidative stress, lipid peroxidation and serum cholinesterase activity, which may in turn, affect lipoproteins metabolism. ةاصلخلا دقل تممص هذه ةساردلا ريدقتل ةيلاعف ميزنا نيلومكلا زيرتمسا يف لصم مدملا ةفامضأ ىلا تايوتسم ةدسكأ نوهدلا فلمو نوهدملا ديمسكوأو كيرتنلا يف لومصم مد ىضرم يركمسلا عومنلا يناثلا ةعومجمو ةرطيسلا نم لجا ةفرعم اميف اذا تناك كانه تاريغت يف .اهتايوتسم دقو ترمهظأ جئامتن ةساردلا دومجو تامعافترا ةيونعم ) P < 0.001 يف ( تايوتمسم لك نم ميزمنا نيلوممكلا زيرتممسا ةدمسكاو نوهدملا lipid peroxidation ةلثمتملا يف MDA يف , ىضرم يركمسلا ةنراقم ةعومجمب اذه .هرطيسلا مغرلابو نم عافترا تايوتسم تيرتمنلا ةرومصب ريمغ نامف م,ةميونعم 283
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- ءايميكلا مولعل ةينطولا ةيقارعلا ةلجملا 2011 نوعبرلاو يناثلا دلجملا Iraqi National Journal of Chemistry,2011,volume 42,283-298 تارتنلا دق تعفترا لكشب يونعم ) P < 0.001 امأ .( ةبسنلاب ىلا فلم نوهدلا دقف
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