Bioinformatics Worksheet - Bioinformatics Worksheet Ex A Your protein’s code letter(e.g Z and name(e.g triosephosphate isomerase Protein A Cellular

Bioinformatics Worksheet - Bioinformatics Worksheet Ex A...

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Bioinformatics Worksheet Ex. A Your protein’s code letter (e.g. Z) and name (e.g., triosephosphate isomerase) Protein A : Cellular tumor antigen p53 Its UniProt locus code (e.g., TPIS_HUMAN) P53_HUMAN Its gene name (e.g., TPI1) TP53 Ex. B What human chromosome is your protein’s gene on? 17 The length of your protein’s gene in base pairs 2331 base pairs Ex. C Using UniProt, summarize your protein’s function: It acts a tumor suppressor. It induces growth arrest/apoptosis. It is involved in cell cycle regulation, where it acts as a trans-activator that negatively regulates cell division. Does your protein have any role in disease? Found in increased amounts in a wide variety of cells. TP53 is frequently mutated or inactivated in 60% of cancers. The mutation of it is found in esophageal cancer, Li-Fraumeni syndrome, lung cancer, the papilloma of choroid plexus, basal cell carcinoma, bone marrow failure syndrome 5, and other diseases.
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  • Fall '15
  • CharlotteKelley

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