Pharmacology of Anti Psychotic Drugs.pptx - PHARMACOLOGY OF ANTIPSYCHOTIC DRUGS PMC 210 By SAINI KENNEDY L FACULTY OF MEDICINE LUSAKA APEX MEDICAL

Pharmacology of Anti Psychotic Drugs.pptx - PHARMACOLOGY OF...

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PHARMACOLOGY OF ANTIPSYCHOTIC DRUGS PMC 210 By SAINI KENNEDY L. FACULTY OF MEDICINE LUSAKA APEX MEDICAL UNIVERSITY
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LEARNING OBJECTIVES At the end of the lecture each student should be able to: i. Define psychosis and antipsychotic drugs. ii. Outline the classification of antipsychotics. iii. Demonstrate knowledge of the pharmacology of Antipsychotics. iv. Explain the advantages of (A)/typical Antipsychotics. 10/22/2019 SAINI KENNEDY L. 2
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ANTIPSYCHOTIC DRUGS Antipsychotic drugs are drugs used to control manifestations of Psychosis. Psychosis is a mental illness in which the mind is separated from reality. SAINI KENNEDY L. 3
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MANIFESTATIONS OF PSYCHOSIS 1. Hallucinations : - Perception without an external stimulus. Patient sees or hears things that don’t exist. 2. Delusions : - False beliefs. They may be paranoid (suspicion), persecutory (Patient believes people are against him) or Grandiose (Patient believes he is a genius or a messenger from God). 3. Incoherent (meaningless) speech . 4. Abnormal behavior : - Aggression and agitation. SAINI KENNEDY L. 4
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SCHIZOPHRENIA The Greek translation is schizein “split” and phren “mind” which refers to a split from reality. It is the most common and most classic example of Psychosis. At first, Patient presents with positive symptoms (e.g. Hallucinations and Delusions) which show good response to drug treatment. After several years, patient may present with negative symptoms (Flat emotions, social withdrawal and intellectual dysfunction) due to brain atrophy. Negative symptoms show poor response to drug treatment. SAINI KENNEDY L. 5
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DOPAMINE THEORY OF PSYCHOSIS SAINI KENNEDY L. 6 Put forward by Arvid Carlsson According to this theory, Psychosis is caused by increased dopaminergic activity in the brain mesolimbic system. Mechanism of action of Antipsychotics All Antipsychotics block Dopamine D 2 receptors in the mesolimbic system.
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CLASSIFICATION OF ANTIPSYCHOTICS A. Typical/Classical Antipsychotics : - They are Dopamine antagonists. They include; 1. Phenothiazines: a. Aliphatic side chain: Chlorpromazine, Triflupromazine b. Piperidine side chain: Thioridazine c. Piperazine side chain: Trifluoperazine, Fluphenazine
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  • Fall '18
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